Experimental Medicine Research Center

Experimental Medicine Research Center has been established to promote research in medical sciences, provide appropriate models for pathophysiological examination of various diseases and their exploitation with the clinic. The goal will be discovering scientific findings and their logical association from lab to clinic.

The research center has developed a program for achieving its main goals, which in brief is as follow:

• Definition and use of cited and standard models in the pathophysiological studies of common diseases in the count1y with diagnostic, and therapeutic or preventive value and also the use of chemical agents for the discove1y of biological processes.
• The logical link between the findings of basic medical sciences and the clinic in order to achieve rapid, rational and effective treatment of the diseases.
• This research center is able in pursuance of its long-term goals to attract research topics of the day, produce science, and publish articles. There is also succeed to establish relations and agreements with domestic and foreign scientific centers, hold an educational workshop and training as well as scientific discussion sessions.

Experimental methods in biomedicine such as cancer, multiple sclerosis, alzheimer's, heart and respirat01y disease, diabetes methods and etc., Fundamental and Applied Toxicology and Phannacology, Applied new Teclmologies (nanomedicine, tissue engineering, imaging etc.), and Translational medicine.

International cooperation includes research and publication of papers and patents in collaboration with international scientific and research centers as follow:

• Division of Research and Development, Pharmin USA, LLC, San Jose, USA.
• The Whittington Hospital NHS Trust, London, United Kingdom.
• Private practice, Houston, Texas.
• Cutaneous Biology Research Center, Massachusetts General Hospital, Charlestown, MA, USA.
• UQ Center for Clinical Research, Department of Molecular Pathology, University of Queensland, Australia.
• Department of Phannacology and Therapeutics, National University of Ireland, Galway, Ireland.
• School of Phannacy, University of Carnerino, Carnerino, Italy.
• Regenerative Medicine Program, Department ofBiochemist1y and Medical Genetics, Rady College of Medicine, Max Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada.
• Department of Biotechnology, Alagappa University, Karaikudi, 630 003, Tamil Nadu, India.
• Department of Phannacognosy, Faculty of Phannacy, Gazi University, 06330, Ankara,Turkey.
• Laborat01y for Translational Oncology and Personalized Medicine, Rashid Latif Medical College, Lahore, 54000, Pakistan.
• Research Group on Community Nutrition and Oxidative Stress (NUCOX) and CIBEROBN (Physiopathology of Obesity and Nutrition CB 12/03/30038), University of Balear·ic Islands, Palma de Mallorca, E-07122, Balearic Islands, Spain.
• Russell H. Morgan Department of Radiology and Radiological Science, J olms Hopkins University School of Medicine, Baltimore, MD, USA.
• Depaitment of Physiology, Faculty of Phannacy, University of Seville, Seville, Spain.
• Depaitment of Chemistiy/ICET, Federal University of Mato Grosso (UFMT), Av. Fernando Correa da Costa, 2367, Cuiaba, MT, 78060-900, Brazil.
• Institute de Investigaci6n e Innovaci6n en Salud, Facultad de Ciencias de la Salud, Universidad Central de Chile, Santiago, Chile.
• Depaitment of Psychiat1y and Neuroscience, Faculty of Medicine, CERVO Brain Research Centre, Laval University, Quebec, G lJ 2G3, Canada.
• Cancer Cell Signaling, Turku Center for Biotechnology, University of Turku and AboAkademi University, Turku, Finland.
• Key Laborat01y of Integrated Management of Crop Diseases and Pests, College of Plant Protection, Nanjing Agriculture University, Nanjing, 210095, PR China.
• Phannacognosy Research Laboratories & Herbal Analysis Se1vices UK, University of Greenwich, Chatham-Maritime, Kent ME4 4TB, UK.
• Depaitment of Phannacognosy, Faculty of Phannacy, Medical University of Bialystok, ul. Mickiewicza 2a, 15-230 Bialystok, Poland.
• Center for Study in Animal Science (CECA), ICETA, University of Oporto, Oporto 4051-401, Portugal.
• Centre for Healthy Brain Ageing, School of Psychiatiy, University of New South Wales, Australia.

• PhD by research
• Post doc

Head of the Center: Pro. Ahinad Reza Dehpour

Vice of the Center: Pro. Sham·am Ejtemaei Melli·

Center Faculty Members:

1. Pro. A.hinad Reza Dehpour

Scholar link: https:Uscholar.google.com/citations?user=en8lsAoAAAAJ&hl=en&oi=ao

Email: dehpour@yahoo.com; dehpoura@sina.tums.ac.ir

Tel: +98 21 88973652

2. Pro. Shahrarn Ejtemaei Mehr

Scholar link: https:Uscholar.google.com/citations?user=mtxuOacAAAAJ&hl=en&oi=ao

Email: ejtemam@tums.ac.ir

3. Dr. Alireza Paitoazar

Scholar link: https://scholar.google.com/citations?user=fUnTHFcAAAAJ&hl=en&oi=ao

Email: paitoazar@yahoo.com

Tel: +98 21 64432604

4. Dr. Razieh Mohainmad Jafari

Scholar link: https:ljscholar.google.com/citations?user=ynLCX2EAAAAJ&hl=en&oi=ao

Email: rmjafa1i@sina.tums.ac.ir

Research Assistant:

1. Nastai·an Rahimi

Scholar link: htt ps:ljscholar.google.com/citations?user=HnfsV4AAAAJ&hl=en&oi=ao

Email: nastaran.rahimee@gmail.com; n-rahimi@fai·abi.tums.ac.ir

Tel: +98 21 64432581

2. Hedyeh Faghir-Ghanesefat

Scholar link: https:Uscholar.google.com/citations?user=feCeBlwAAAAJ&hl=en&oi=sra

Email: h_ghanesefat@yahoo.com

3. Adeleh Maleki

Email: a maleki84@yahoo.com

4. Taraneh Balu·emand

Scholar link: https:Uscholar.google.com/citations?user=fK6uYloAAAAJ&hl=en&oi=ao

5. Nazgol-Sadat Haddadi

Scholar link: https:Uscholar.google.com/citations?user=xPHvS2UAAAAJ&hl=en&oi=ao

1. Lithium attenuates the proconvulsant effect of adolescent social isolation stress via involvement of the nitrergic system.
2. Anti-tumour activity of tivozanib, a pan-inhibitor of VEGF receptors, in therapy-resistant ovarian carcinoma cells.
3. Involvement of central opioid receptors in protective effects of methadone on experimental colitis in rats.
4. Acute foot-shock stress decreased seizure susceptibility against pentylenetetrazole-induced seizures in mice: Interaction between endogenous opioids and cannabinoids.
5. Anxiety- and Depressive-Like Behaviors are Associated with Altered Hippocampal Energy and Inflammat01y Status in a Mouse Model of Crohn's Disease.
6. Oxytocin mitigated the depressive-like behaviors of maternal separation stress through modulating mitochondrial function and neuroinflammation.

Center Address: Experimental Medicine Research Center (next to the Depaitment of Pharmacology), School of Medicine, St. Poursina, and Keshavarz Blvd, Tehran, Iran.

Tell: +98 21 88973652

Fax: + 98 21 66402569

Email of the Center: exmedicine@sina.tums.ac.ir; exmedicine@gmail.com

Web Center: http://emrec.tums.ac.ir/