How I Treat Acute Lymphoblastic Leukemia?

Dr. Ashkan Emadi

Professor Of Medicine and Pharmacology, Associate Director for Clinical Research at University of Maryland, Greenebaum Comprehensive Cancer Center, Director of Translational Genomics Laboratory, University of Maryland School of Medicine, USA

Dr. Ashkan Emadi, MD, PhD is a hematologist, medical oncologist and an organic chemist who is a Professor of Medicine and Pharmacology at the University of Maryland School Of Medicine, and Greenebaum Comprehensive Cancer Center (UMGCCC). Currently, he is the Associate Director for Clinical Research and the Director of Translational Genomics Laboratory at UMGCCC. Dr. Emadi’s clinical practice focuses on acute leukemias, and his areas of expertise include molecular pharmacology, cancer metabolism and the regulatory aspects of cancer-related clinical trials. His clinical translational investigations are focused on:

1. Targeting glutamine metabolism and mTOR-eIF4E-driven ribosomal translational protein synthesis apparatus in acute leukemia and pancreatic adenocarcinoma cells and their microenvironment (asparaginase/crisantaspase combination therapy)

2. Overcoming resistance to FLT3, Bcl-2 & Mcl-1 inhibitors

3. Cancer immunotherapy including:

a) Bi-specific T-cell engagers (BiTEs) in ALL, AML and MPAL

b) targeting indoleamine 2, 3-dioxygenase(IDO)/ tryptophan pathway in AML