Breakthrough in Diabetic Wound Healing: Stem Cell-Loaded Nanofiber Scaffold Speeds Recovery and Reduces Amputation Risks

02 December 2024 | 15:35 Code : 1226 News
visits:150
A new study demonstrates that mesenchymal stem cells (MSCs) combined with a nanofibrous scaffold can significantly enhance wound healing in diabetic patients, offering hope for reducing amputation risks. This innovative scaffold delivers stem cells to wounds, promoting faster healing, better tissue regeneration, and reduced inflammation. The MSC-loaded scaffold outperformed acellular alternatives and exhibited excellent biocompatibility and biodegradability, making it a promising advancement in diabetic wound care.

Summary: A pioneering study has shown that mesenchymal stem cells (MSCs) combined with a novel nanofibrous biomaterial can dramatically improve wound healing in diabetic patients, offering hope for those at risk of amputation. Researchers developed a controlled polymeric scaffold that successfully delivers stem cells to diabetic wounds, addressing the challenges of cell retention and viability. This new treatment strategy accelerated the healing of chronic diabetic ulcers, offering a potential game-changer for advanced wound care.

Key Findings:

  • Nanofibrous Scaffold: The scaffold, made from a polymeric solution, was designed to deliver stem cells directly to the injury site.
  • Stem Cells Used: Human adipose-derived mesenchymal stem cells (ADMSCs) and placenta-derived stem cells (PLMSCs) were used for the study.
  • Enhanced Healing: The stem cell-loaded scaffold resulted in accelerated wound closure, improved tissue regeneration, and reduced inflammation in diabetic rats.
  • Superior to Acellular Scaffold: The MSC-loaded scaffold outperformed an acellular version, showing superior healing effects.
  • Biocompatibility and Stability: The scaffold exhibited ideal properties for wound healing, including proper swelling, hydrophilicity, biodegradation, and cell attachment.

This innovative approach offers a promising alternative to traditional diabetic wound treatments and could significantly reduce the risk of complications in diabetic patients.

Article: “Chitosan based extruded nanofibrous bioscaffold for local delivery of mesenchymal stem cells to improve diabetic wound healing”

Author: Seyed Nasser Ostad

Professor of Pharmacology and Toxicology

Department of Pharmaceutical Biomaterials, School of Pharmacy

Tehran University of Medical Sciences

Journal: Stem Cell Research and Therapy - IF: 7.1

Read More: https://pubmed.ncbi.nlm.nih.gov/39148112/

DOI: DOI

  science-communication@tums.ac.ir

( 1 )

Your Comment :